The effects of venlafaxine on depressive-like behaviors and gut microbiome in cuprizone-treated mice.
Front Psychiatry
; 15: 1347867, 2024.
Article
em En
| MEDLINE
| ID: mdl-38899045
ABSTRACT
Background:
Cuprizone (CPZ)-treated mice show significant demyelination, altered gut microbiome, and depressive-like behaviors. However, the effects of venlafaxine (Ven) on the gut microbiome and depressive-like behavior of CPZ-treated mice are largely unclear.Methods:
Male C57BL/6J mice were fed a chow containing 0.2% cuprizone (w/w) for 5 weeks to induce a model of demyelination. Meanwhile, the gut microbiota and depressive-like behaviors were assessed after the mice were fed with Ven (20 mg/kg/day) or equal volumes of distilled water for 2 weeks by oral gavage from the third week onward during CPZ treatment.Results:
CPZ treatment decreased the sucrose preference rate in the sucrose preference test and increased the immobility time in the tail-suspension test, and it also induced an abnormality in ß-diversity and changes in microbial composition. Ven alleviated the depressive-like behavior and regulated the composition of the gut microbiota, such as the increase of Lactobacillus and Bifidobacterium in CPZ-treated mice.Conclusion:
The anti-depressant effects of Ven might be related to the regulation of gut microbiota in the CPZ-treated mice.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Front Psychiatry
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China