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Cavitation-on-a-Chip Enabled Size-Specific Liposomal Drugs for Selective Pharmacokinetics and Pharmacodynamics.
Shan, Han; Yu, Nianzhou; Chen, Maike; Sun, Qi; Sun, Xin; Du, Changsheng; Shang, Wansong; Li, Zhaoxi; Wei, Xiongwei; Lin, Qibo; Jiang, Zixi; Chen, Ziyan; Zhu, Benpeng; Zhao, Shuang; Chen, Zeyu; Chen, Xiang.
Afiliação
  • Shan H; Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
  • Yu N; National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha 410008, China.
  • Chen M; Furong Laboratory, Changsha 410008, China.
  • Sun Q; State Key Laboratory of Precision Manufacturing for Extreme Service Performance, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.
  • Sun X; Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
  • Du C; National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha 410008, China.
  • Shang W; Furong Laboratory, Changsha 410008, China.
  • Li Z; Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
  • Wei X; National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha 410008, China.
  • Lin Q; Furong Laboratory, Changsha 410008, China.
  • Jiang Z; State Key Laboratory of Precision Manufacturing for Extreme Service Performance, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.
  • Chen Z; State Key Laboratory of Precision Manufacturing for Extreme Service Performance, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.
  • Zhu B; Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
  • Zhao S; Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
  • Chen Z; The School of Microelectronics, Xidian University, Xi'an 710071, China.
  • Chen X; The School of Microelectronics, Xidian University, Xi'an 710071, China.
Nano Lett ; 24(26): 8151-8161, 2024 Jul 03.
Article em En | MEDLINE | ID: mdl-38912914
ABSTRACT
The size of liposomal drugs has been demonstrated to strongly correlate with their pharmacokinetics and pharmacodynamics. While the microfluidic method successfully achieves the production of liposomes with well-controlled sizes across various buffer/lipid flow rate ratio (FRR) settings, any adjustments to the FRR inevitably influence the concentration, encapsulation efficiency (EE), and stability of liposomal drugs. Here we describe a controllable cavitation-on-a-chip (CCC) strategy that facilitates the precise regulation of liposomal drug size at any desired FRR. The CCC-enabled size-specific liposomes exhibited striking differences in uptake and biodistribution behaviors, thereby demonstrating distinct antitumor efficacy in both tumor-bearing animal and melanoma patient-derived organoid (PDO) models. Intriguingly, as the liposome size decreased to approximately 80 nm, the preferential accumulation of liposomal drugs in the liver transitioned to a predominant enrichment in the kidneys. These findings underscore the considerable potential of our CCC approach in influencing the pharmacokinetics and pharmacodynamics of liposomal nanomedicines.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dispositivos Lab-On-A-Chip / Lipossomos Limite: Animals / Humans Idioma: En Revista: Nano Lett Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dispositivos Lab-On-A-Chip / Lipossomos Limite: Animals / Humans Idioma: En Revista: Nano Lett Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China