Unlocking the therapeutic potential of locked nucleic acids through lipid nanoparticle delivery.
Mol Ther Nucleic Acids
; 35(2): 102224, 2024 Jun 11.
Article
em En
| MEDLINE
| ID: mdl-38933259
ABSTRACT
Locked nucleic acids (LNAs) are a subtype of antisense oligonucleotides (ASOs) that are characterized by a bridge within the sugar moiety. LNAs owe their robustness to this chemical modification, which as the name suggests, locks it in one conformation. This perspective includes two components a general overview on ASOs from one side and on delivery issues focusing on lipid nanoparticles (LNPs) on the other side. Throughout, a screening of the ongoing clinical trials involving ASOs is given, as well as a take on the versatility and challenges of using LNAs. Finally, we highlight the potential of LNPs as carriers for the successful delivery of LNAs.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Mol Ther Nucleic Acids
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Israel
País de publicação:
Estados Unidos