Observable Atrial and Ventricular Fibrillation Episode Durations Are Conformant With a Power Law Based on System Size and Spatial Synchronization.
Circ Arrhythm Electrophysiol
; 17(7): e012684, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38939983
ABSTRACT
BACKGROUND:
Atrial fibrillation (AF) and ventricular fibrillation (VF) episodes exhibit varying durations, with some spontaneously ending quickly while others persist. A quantitative framework to explain episode durations remains elusive. We hypothesized that observable self-terminating AF and VF episode lengths, whereby durations are known, would conform with a power law based on the ratio of system size and correlation length ([Formula see text].METHODS:
Using data from computer simulations (2-dimensional sheet and 3-dimensional left-atrial), human ischemic VF recordings (256-electrode sock, n=12 patients), and human AF recordings (64-electrode basket-catheter, n=9 patients; 16-electrode high definition-grid catheter, n=42 patients), conformance with a power law was assessed using the Akaike information criterion, Bayesian information criterion, coefficient of determination (R2, significance=P<0.05) and maximum likelihood estimation. We analyzed fibrillatory episode durations and [Formula see text], computed by taking the ratio between system size ([Formula see text], chamber/simulation size) and correlation length (xi, estimated from pairwise correlation coefficients over electrode/node distance).RESULTS:
In all computer models, the relationship between episode durations and [Formula see text] was conformant with a power law (Aliev-Panfilov R2 0.90, P<0.001; Courtemanche R2 0.91, P<0.001; Luo-Rudy R2 0.61, P<0.001). Observable clinical AF/VF durations were also conformant with a power law relationship (VF R2 0.86, P<0.001; AF basket R2 0.91, P<0.001; AF grid R2 0.92, P<0.001). [Formula see text] also differentiated between self-terminating and sustained episodes of AF and VF (P<0.001; all systems), as well as paroxysmal versus persistent AF (P<0.001). In comparison, other electrogram metrics showed no statistically significant differences (dominant frequency, Shannon Entropy, mean voltage, peak-peak voltage; P>0.05).CONCLUSIONS:
Observable fibrillation episode durations are conformant with a power law based on system size and correlation length.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fibrilação Atrial
/
Fibrilação Ventricular
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Circ Arrhythm Electrophysiol
Assunto da revista:
ANGIOLOGIA
/
CARDIOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article