Advances in noncoding RNA in children allergic rhinitis.
Int Forum Allergy Rhinol
; 14(8): 1350-1362, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38946149
ABSTRACT
BACKGROUND:
A chronic condition that significantly reduces a child's quality of life is allergic rhinitis (AR). The environment and allergens that the body is regularly exposed to can cause inflammatory and immunological reactions, which can change the expression of certain genes Epigenetic changes are closely linked to the onset and severity of allergy disorders according to mounting amounts of data. Noncoding RNAs (ncRNAs) are a group of RNA molecules that cannot be converted into polypeptides. The three main categories of ncRNAs include microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). NcRNAs play a crucial role in controlling gene expression and contribute to the development of numerous human diseases.METHODS:
Articles are selected based on Pubmed's literature review and the author's personal knowledge. The largest and highest quality studies were included. The search selection is not standardized.RESULTS:
Recent findings indicate that various categories of ncRNAs play distinct yet interconnected roles and actively contribute to intricate gene regulatory networks.CONCLUSION:
This article demonstrates the significance and progress of ncRNAs in children's AR. The database covers three key areas miRNAs, lncRNAs, and circRNAs. Additionally, potential avenues for future research to facilitate the practical application of ncRNAs as therapeutic targets and biomarkers will be explore.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA não Traduzido
/
Rinite Alérgica
Limite:
Child
/
Humans
Idioma:
En
Revista:
Int Forum Allergy Rhinol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China