Fit for purpose: Selecting the best mitochondrial DNA for the job.

Pickett, Sarah J; Taylor, Robert W; McFarland, Robert

Pickett, Sarah J; Taylor, Robert W; McFarland, Robert.

Afiliação

Pickett SJ; Mitochondrial Research Group, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Taylor RW; Mitochondrial Research Group, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK.
McFarland R; Mitochondrial Research Group, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK. Electronic address: robert.mcfarland@ncl.ac.uk.

Cell Metab ; 36(7): 1436-1438, 2024 Jul 02.

Article em En | MEDLINE | ID: mdl-38959860

ABSTRACT

ABSTRACT

The factors determining levels of pathogenic mitochondrial DNA in cells and tissues are critical to disease pathology but remain poorly understood and contentious. In Nature, Kotrys et al. published a single-cell-based analysis casting fresh light on this thorny problem and introduced a powerful new investigative tool.

Assuntos

DNA Mitocondrial; DNA Mitocondrial/genética; Humanos; Mitocôndrias/metabolismo; Mitocôndrias/genética; Análise de Célula Única/métodos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA Mitocondrial Limite: Humans Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos

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