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Synergy between nanoplastics and benzo[a]pyrene promotes senescence by aggravating ferroptosis and impairing mitochondria integrity in Caenorhabditis elegans.
Ren, Huasheng; Yin, Kai; Lu, Xinhe; Liu, Jiaojiao; Li, Dandan; Liu, Zuojun; Zhou, Hailong; Xu, Shunqing; Li, Hanzeng.
Afiliação
  • Ren H; School of Life and Health Sciences, Hainan University, Haikou 570228, China.
  • Yin K; School of Life and Health Sciences, Hainan University, Haikou 570228, China.
  • Lu X; School of Life and Health Sciences, Hainan University, Haikou 570228, China.
  • Liu J; School of Life and Health Sciences, Hainan University, Haikou 570228, China.
  • Li D; School of Environmental Science and Engineering, Hainan University, Haikou 570228, China.
  • Liu Z; School of Environmental Science and Engineering, Hainan University, Haikou 570228, China.
  • Zhou H; School of Life and Health Sciences, Hainan University, Haikou 570228, China. Electronic address: zhouhl@hainanu.edu.cn.
  • Xu S; School of Environmental Science and Engineering, Hainan University, Haikou 570228, China. Electronic address: xus@hainanu.edu.cn.
  • Li H; School of Environmental Science and Engineering, Hainan University, Haikou 570228, China. Electronic address: hanzeng.li@hainanu.edu.cn.
Sci Total Environ ; 946: 174418, 2024 Oct 10.
Article em En | MEDLINE | ID: mdl-38960162
ABSTRACT
Micro-nano plastics have been reported as important carriers of polycyclic aromatic hydrocarbons (PAHs) for long-distance migration in the environment. However, the combined toxicity from long-term chronic exposure beyond the vehicle-release mechanism remains elusive. In this study, we investigated the synergistic action of Benzo[a]pyrene (BaP) and Polystyrene nanoparticles (PS) in Caenorhabditis elegans (C. elegans) as a combined exposure model with environmental concentrations. We found that the combined exposure to BaP and PS, as opposed to single exposures at low concentrations, significantly shortened the lifespan of C. elegans, leading to the occurrence of multiple senescence phenotypes. Multi-omics data indicated that the combined exposure to BaP and PS is associated with the disruption of glutathione homeostasis. Consequently, the accumulated reactive oxygen species (ROS) cannot be effectively cleared, which is highly correlated with mitochondrial dysfunction. Moreover, the increase in ROS promoted lipid peroxidation in C. elegans and downregulated Ferritin-1 (Ftn-1), resulting in ferroptosis and ultimately accelerating the aging process of C. elegans. Collectively, our study provides a new perspective to explain the long-term compound toxicity caused by BaP and PS at real-world exposure concentrations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzo(a)pireno / Espécies Reativas de Oxigênio / Caenorhabditis elegans / Ferroptose / Mitocôndrias Limite: Animals Idioma: En Revista: Sci Total Environ Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzo(a)pireno / Espécies Reativas de Oxigênio / Caenorhabditis elegans / Ferroptose / Mitocôndrias Limite: Animals Idioma: En Revista: Sci Total Environ Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Holanda