A Mendelian randomization study: Years of education and nonalcoholic fatty liver disease.
Medicine (Baltimore)
; 103(27): e38761, 2024 Jul 05.
Article
em En
| MEDLINE
| ID: mdl-38968508
ABSTRACT
Though years of education have been connected to nonalcoholic fatty liver disease (NAFLD), the exact mechanism underlying this linkage is still unknown. To investigate the causal association between years of education and NAFLD, we will use a 2-sample Mendelian randomization (MR) technique. Genome-wide association studies data on years of education (nâ
=â
766,345) and genome-wide association studies data on nonaffiliated mental illness (nâ
=â
778,614) were screened for genetic variations as instrumental variables in the Mr-Base database. MR-Egger regression, weighted median, and inverse variance weighted were used in the MR analysis. Years of education (odds ratioâ
=â
0.63; 95% confidence interval 0.47-0.79; Pâ
=â
1.28â
×â
10-8) might be protective against the development of NAFLD. Among the sensitivity analyses were the following the MR-Egger intercept test revealed Pâ
>â
.05, suggesting that there was no horizontal pleiotropy in the MR analysis and that the inverse variance weighted results were trustworthy; the Cochran Q test revealed Pâ
>â
.05, suggesting that there was no heterogeneity between the 2 samples; Funnel plot results demonstrated that there was no bias in the link between the measure of variability and the impact size. Leave-1-out analysis results demonstrated that no 1 single nucleotide polymorphism had a significant effect on the study's results, showing that the MR results were stable. This study has investigated the connection between years of education and NAFLD, offering novel suggestions for NAFLD treatment and prevention.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estudo de Associação Genômica Ampla
/
Análise da Randomização Mendeliana
/
Hepatopatia Gordurosa não Alcoólica
Limite:
Humans
Idioma:
En
Revista:
Medicine (Baltimore)
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China
País de publicação:
Estados Unidos