Melatonin improves fertilization rate in assisted reproduction: Systematic review and meta-analysis.
Clinics (Sao Paulo)
; 79: 100397, 2024.
Article
em En
| MEDLINE
| ID: mdl-38971124
ABSTRACT
BACKGROUND:
Melatonin is a hormone produced by the pineal gland and it has antioxidant properties.AIM:
This study aimed to evaluate the effects of melatonin on assisted reproductive technologies through a systematic review and a meta-analysis. MATERIALS ANDMETHODS:
Search strategies were used in PubMed and in other databases covering the last 15 years. After screening for eligibility, 17 articles were selected for the systematic review. For the meta-analysis statistics, two groups were formed, the treatment group (with melatonin) and the control group (without melatonin) for various assisted reproduction outcomes.RESULTS:
The main results were that no statistical differences were found concerning the clinical pregnancy outcome (p = 0.64), but there was a statistical difference with respect to Mature Oocytes (MII) (p = 0.001), antral follicle count (p = 0.0002), and the fertilization rate (p ≤ 0.0001).CONCLUSIONS:
Melatonin had beneficial effects such as the improvement in the fertilization rate, although the authors did not obtain significance in the clinical pregnancy rate.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Taxa de Gravidez
/
Melatonina
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Clinics (Sao Paulo)
Assunto da revista:
MEDICINA
Ano de publicação:
2024
Tipo de documento:
Article