Neural pathways that compel us to scratch an itch.
J Biosci
; 492024.
Article
em En
| MEDLINE
| ID: mdl-38973668
ABSTRACT
Itch is a unique sensory experience that is responded to by scratching. How pruritogens, which are mechanical and chemical stimuli with the potential to cause itch, engage specific pathways in the peripheral and central nervous system has been a topic of intense investigation over the last few years. Studies employing recently developed molecular, physiological, and behavioral techniques have delineated the dedicated mechanisms that transmit itch information to the brain. This review outlines the genetically defined and evolutionary conserved circuits for itch ranging from the skin-innervating peripheral neurons to the cortical neurons that drive scratching. Moreover, scratch suppression of itch is attributed to the concurrent activation of pain and itch pathways. Hence, we discuss the similarities between circuits driving pain and itch.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prurido
/
Vias Neurais
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Biosci
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Índia