Towards a comprehensive bedside swallow screening protocol using cross-domain transformation and high-resolution cervical auscultation.

ABSTRACT

High-resolution cervical auscultation (HRCA) is an emerging noninvasive and accessible option to assess swallowing by relying upon accelerometry and sound sensors. HRCA has shown tremendous promise and accuracy in identifying and predicting swallowing physiology and biomechanics with accuracies equivalent to trained human judges. These insights have historically been available only through instrumental swallowing evaluation methods, such as videofluoroscopy and endoscopy. HRCA uses supervised learning techniques to interpret swallowing physiology from the acquired signals, which are collected during radiographic assessment of swallowing using barium contrast. Conversely, bedside swallowing screening is typically conducted in non-radiographic settings using only water. This poses a challenge to translating and generalizing HRCA algorithms to bedside screening due to the rheological differences between barium and water. To address this gap, we proposed a cross-domain transformation framework that uses cycle generative adversarial networks to convert HRCA signals of water swallows into a domain compatible with the barium swallows-trained HRCA algorithms. The proposed framework achieved a cross-domain transformation accuracy that surpassed 90%. The authenticity of the generated signals was confirmed using a binary classifier to confirm the framework's capability to produce indistinguishable signals. This framework was also assessed for retaining swallow physiological and biomechanical properties in the signals by applying an existing model from the literature that identifies the opening and closure of the upper esophageal sphincter. The outcomes of this model showed nearly identical results between the generated and original signals. These findings suggest that the proposed transformation framework is a feasible avenue to advance HCRA towards clinical deployment for water-based swallowing screenings.