A smart hypochlorous acid fluorescent probe enabling Ibuprofen-release for osteoarthritis theranostics.
Theranostics
; 14(10): 3900-3908, 2024.
Article
em En
| MEDLINE
| ID: mdl-38994024
ABSTRACT
Background:
Osteoarthritis (OA) standing as the most prevalent form of arthritis, closely associates with heightened levels of reactive oxygen species, particularly hypochlorous acid (HOCl). Although there are numerous probes available for detecting HOCl in the OA region, probes with dual functions of diagnostic and therapeutic capabilities are still significantly lacking. While this type of probe can reduce the time gap between diagnosis and treatment, which is clinically needed.Methods:
We developed a fluorescent probe (DHU-CBA1) toward HOCl with theranostics functions through the release of methylene blue (MB) and ibuprofen (IBP) in this work. DHU-CBA1 can detect HOCl with high specificity and sensitivity, releasing MB and IBP with an impressive efficiency of ≥ 95% in vitro.Results:
DHU-CBA1 exhibits good biosafety, enabling in vivo imaging of endogenous HOCl, along with reducing arthritis scores, improving synovitis and cartilage damage, and maintaining catabolic balance while alleviating senescence in cartilage.Conclusions:
This study proposes a novel approach to enhance osteoarthritis therapy by releasing IBP via a smart HOCl-enabled fluorescent probe.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoartrite
/
Ibuprofeno
/
Ácido Hipocloroso
/
Corantes Fluorescentes
/
Azul de Metileno
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Theranostics
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China