SignalP: The Evolution of a Web Server.

Nielsen, Henrik; Teufel, Felix; Brunak, Søren; von Heijne, Gunnar

Nielsen, Henrik; Teufel, Felix; Brunak, Søren; von Heijne, Gunnar.

Afiliação

Nielsen H; Section for Bioinformatics, Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark. henni@dtu.dk.
Teufel F; Bioinformatics Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Brunak S; Digital Science & Innovation, Novo Nordisk A/S, Malov, Denmark.
von Heijne G; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Methods Mol Biol ; 2836: 331-367, 2024.

Article em En | MEDLINE | ID: mdl-38995548

ABSTRACT

ABSTRACT

SignalP ( https//services.healthtech.dtu.dk/services/SignalP-6.0/ ) is a very popular prediction method for signal peptides, the intrinsic signals that make proteins secretory. The SignalP web server has existed since 1995 and is now in its sixth major version. In this historical account, we (three authors who have taken part in the entire journey plus the first author of the latest version) describe the differences between the versions and discuss the various decisions taken along the way.

Assuntos

Internet; Sinais Direcionadores de Proteínas; Software; Biologia Computacional/métodos; Humanos

Palavras-chave

Hidden Markov model; Neural network; Protein language model; Signal peptide

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Software / Sinais Direcionadores de Proteínas / Internet Limite: Humans Idioma: En Revista: Methods Mol Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Dinamarca País de publicação: Estados Unidos

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google