Tumor-intrinsic P2RY6 drives immunosuppression by enhancing PGE<sub>2</sub> production.

Xu, Xilong; Lu, Yi; Cao, Longzhi; Miao, Yang; Li, Yamei; Cui, Yue; Han, Ting

Tumor-intrinsic P2RY6 drives immunosuppression by enhancing PGE₂ production.

Xu, Xilong; Lu, Yi; Cao, Longzhi; Miao, Yang; Li, Yamei; Cui, Yue; Han, Ting.

Afiliação

Xu X; College of Life Sciences, Beijing Normal University, Beijing 100875, China; National Institute of Biological Sciences, Beijing 102206, China.
Lu Y; National Institute of Biological Sciences, Beijing 102206, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China.
Cao L; National Institute of Biological Sciences, Beijing 102206, China; Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Miao Y; National Institute of Biological Sciences, Beijing 102206, China; PTN Joint Graduate Program, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Li Y; National Institute of Biological Sciences, Beijing 102206, China; Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Cui Y; College of Life Sciences, Beijing Normal University, Beijing 100875, China; National Institute of Biological Sciences, Beijing 102206, China.
Han T; College of Life Sciences, Beijing Normal University, Beijing 100875, China; National Institute of Biological Sciences, Beijing 102206, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China. Electronic address: hanting@nibs.ac.cn.

Cell Rep ; 43(7): 114469, 2024 Jul 23.

Article em En | MEDLINE | ID: mdl-38996067

Assuntos

Dinoprostona; Microambiente Tumoral; Animais; Dinoprostona/metabolismo; Humanos; Camundongos; Microambiente Tumoral/imunologia; Linhagem Celular Tumoral; Camundongos Endogâmicos C57BL; Neoplasias/imunologia; Neoplasias/metabolismo; Neoplasias/patologia; Terapia de Imunossupressão; Receptores Purinérgicos P2/metabolismo; Tolerância Imunológica; Transdução de Sinais

Palavras-chave

CP: Cancer; CP: Immunology; P2RY6; immunotherapy resistance; prostaglandin E2; tumor microenvironment; tumor immune evasion

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dinoprostona / Microambiente Tumoral Limite: Animals / Humans Idioma: En Revista: Cell Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

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