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Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study - PHOSP-COVID.
Elneima, Omer; Hurst, John R; Echevarria, Carlos; Quint, Jennifer K; Walker, Samantha; Siddiqui, Salman; Novotny, Petr; Pfeffer, Paul E; Brown, Jeremy S; Shankar-Hari, Manu; McAuley, Hamish J C; Leavy, Olivia C; Shikotra, Aarti; Singapuri, Amisha; Sereno, Marco; Richardson, Matthew; Saunders, Ruth M; Harris, Victoria C; Houchen-Wolloff, Linzy; Greening, Neil J; Harrison, Ewen M; Docherty, Annemarie B; Lone, Nazir I; Chalmers, James D; Ho, Ling-Pei; Horsley, Alex; Marks, Michael; Poinasamy, Krisnah; Raman, Betty; Evans, Rachael A; Wain, Louise V; Sheikh, Aziz; Brightling, Chris E; De Soyza, Anthony; Heaney, Liam G.
Afiliação
  • Elneima O; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre - Respiratory, University of Leicester, Leicester, UK.
  • Hurst JR; UCL Respiratory, Department of Medicine, University College London, London, UK.
  • Echevarria C; Royal Free London NHS Foundation Trust, London, UK.
  • Quint JK; Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK.
  • Walker S; Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK.
  • Siddiqui S; School of Public Health, Imperial College London, London, UK.
  • Novotny P; Asthma+Lung UK, London, UK.
  • Pfeffer PE; National Heart and Lung Institute, Imperial College London, London, UK.
  • Brown JS; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre - Respiratory, University of Leicester, Leicester, UK.
  • Shankar-Hari M; Department of Respiratory Medicine, Barts Health NHS Trust, London, UK.
  • McAuley HJC; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Leavy OC; UCL Respiratory, Department of Medicine, University College London, London, UK.
  • Shikotra A; Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.
  • Singapuri A; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre - Respiratory, University of Leicester, Leicester, UK.
  • Sereno M; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre - Respiratory, University of Leicester, Leicester, UK.
  • Richardson M; Department of Population Health Sciences, University of Leicester, Leicester, UK.
  • Saunders RM; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre - Respiratory, University of Leicester, Leicester, UK.
  • Harris VC; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre - Respiratory, University of Leicester, Leicester, UK.
  • Houchen-Wolloff L; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre - Respiratory, University of Leicester, Leicester, UK.
  • Greening NJ; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre - Respiratory, University of Leicester, Leicester, UK.
  • Harrison EM; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre - Respiratory, University of Leicester, Leicester, UK.
  • Docherty AB; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre - Respiratory, University of Leicester, Leicester, UK.
  • Lone NI; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre - Respiratory, University of Leicester, Leicester, UK.
  • Chalmers JD; Centre for Exercise and Rehabilitation Science, NIHR Leicester Biomedical Research Centre-Respiratory, University of Leicester, Leicester, UK.
  • Ho LP; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre - Respiratory, University of Leicester, Leicester, UK.
  • Horsley A; Centre for Medical Informatics, The Usher Institute, University of Edinburgh, Edinburgh, UK.
  • Marks M; Centre for Medical Informatics, The Usher Institute, University of Edinburgh, Edinburgh, UK.
  • Poinasamy K; Centre for Medical Informatics, The Usher Institute, University of Edinburgh, Edinburgh, UK.
  • Raman B; University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
  • Evans RA; MRC Translational Discovery Immunology Unit, University of Oxford, Oxford, UK.
  • Wain LV; NIHR Oxford BRC, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
  • Sheikh A; Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Brightling CE; Manchester University NHS Foundation Trust, Manchester, UK.
  • De Soyza A; Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.
  • Heaney LG; Hospital for Tropical Diseases, University College London Hospital, London, UK.
ERJ Open Res ; 10(4)2024 Jul.
Article em En | MEDLINE | ID: mdl-39010888
ABSTRACT

Background:

The long-term outcomes of COVID-19 hospitalisation in individuals with pre-existing airway diseases are unknown.

Methods:

Adult participants hospitalised for confirmed or clinically suspected COVID-19 and discharged between 5 March 2020 and 31 March 2021 were recruited to the Post-hospitalisation COVID-19 (PHOSP-COVID) study. Participants attended research visits at 5 months and 1 year post discharge. Clinical characteristics, perceived recovery, burden of symptoms and health-related quality of life (HRQoL) of individuals with pre-existing airway disease (i.e., asthma, COPD or bronchiectasis) were compared to the non-airways group.

Results:

A total of 615 out of 2697 (22.8%) participants had a history of pre-existing airway diseases (72.0% diagnosed with asthma, 22.9% COPD and 5.1% bronchiectasis). At 1 year, the airways group participants were less likely to feel fully recovered (20.4% versus 33.2%, p<0.001), had higher burden of anxiety (29.1% versus 22.0%, p=0.002), depression (31.2% versus 24.7%, p=0.006), higher percentage of impaired mobility using short physical performance battery ≤10 (57.4% versus 45.2%, p<0.001) and 27% had a new disability (assessed by the Washington Group Short Set on Functioning) versus 16.6%, p=0.014. HRQoL assessed using EQ-5D-5L Utility Index was lower in the airways group (mean±SD 0.64±0.27 versus 0.73±0.25, p<0.001). Burden of breathlessness, fatigue and cough measured using a study-specific tool was higher in the airways group.

Conclusion:

Individuals with pre-existing airway diseases hospitalised due to COVID-19 were less likely to feel fully recovered, had lower physiological performance measurements, more burden of symptoms and reduced HRQoL up to 1 year post-hospital discharge.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ERJ Open Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ERJ Open Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Reino Unido