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Multiscale homogenization for dual porosity time-dependent Darcy-Brinkman/Darcy coupling and its application to the lymph node.
Girelli, A; Giantesio, G; Musesti, A; Penta, R.
Afiliação
  • Girelli A; Dipartimento di Matematica e Fisica 'N. Tartaglia', Università Cattolica del Sacro Cuore, Brescia, Italy.
  • Giantesio G; Dipartimento di Matematica e Fisica 'N. Tartaglia', Università Cattolica del Sacro Cuore, Brescia, Italy.
  • Musesti A; 'Mathematics for Technology, Medicine and Biosciences', Università degli Studi di Ferrara, Ferrara, Italy.
  • Penta R; Dipartimento di Matematica e Fisica 'N. Tartaglia', Università Cattolica del Sacro Cuore, Brescia, Italy.
R Soc Open Sci ; 11(7): 231983, 2024 Jul.
Article em En | MEDLINE | ID: mdl-39021765
ABSTRACT
We study the coupling between time-dependent Darcy-Brinkman and the Darcy equations at the microscale subjected to inhomogeneous body forces and initial conditions to describe a double porosity problem. We derive the homogenized governing equations for this problem using the asymptotic homogenization technique, and as macroscopic results, we obtain a coupling between two Darcy equations, one of which with memory effects, with mass exchange between phases. The memory effects are a consequence of considering the time dependence in the Darcy-Brinkman equation, and they allow us to study in more detail the role of time in the problem under consideration. After the formulation of the model, we solve it in a simplified setting and we use it to describe the movement of fluid within a vascularized lymph node.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: R Soc Open Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Itália País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: R Soc Open Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Itália País de publicação: Reino Unido