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Enhanced drug resistance suppression by serum-stable micelles from multi-arm amphiphilic block copolymers and tocopheryl polyethylene glycol 1000 succinate.
He, Lei; Jiang, Cheng; Ren, Jing; Pan, Xiaoling; Qiu, Zhiwen; Xia, Yening; Wang, Tian; Guo, Jiahao; Li, Junfang; Li, Wei.
Afiliação
  • He L; School of Health Science & Engineering, University of Shanghai for Science & Technology, Shanghai,  200093, China.
  • Jiang C; Department of Nanomedicine & Shanghai Key Lab of Cell Engineering, Naval Medical University, Shanghai,  200433, China.
  • Ren J; Department of Nanomedicine & Shanghai Key Lab of Cell Engineering, Naval Medical University, Shanghai,  200433, China.
  • Pan X; State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 lingling Lu, Shanghai,  200032, China.
  • Qiu Z; Department of Nanomedicine & Shanghai Key Lab of Cell Engineering, Naval Medical University, Shanghai,  200433, China.
  • Xia Y; Department of Nanomedicine & Shanghai Key Lab of Cell Engineering, Naval Medical University, Shanghai,  200433, China.
  • Wang T; Department of Nanomedicine & Shanghai Key Lab of Cell Engineering, Naval Medical University, Shanghai,  200433, China.
  • Guo J; School of Health Science & Engineering, University of Shanghai for Science & Technology, Shanghai,  200093, China.
  • Li J; Department of Nanomedicine & Shanghai Key Lab of Cell Engineering, Naval Medical University, Shanghai,  200433, China.
  • Li W; School of Health Science & Engineering, University of Shanghai for Science & Technology, Shanghai,  200093, China.
Nanomedicine (Lond) ; 19(14): 1297-1311, 2024.
Article em En | MEDLINE | ID: mdl-39046514
ABSTRACT

Aim:

To develop a robust drug-delivery system using multi-arm amphiphilic block copolymers for enhanced efficacy in cancer therapy. Materials &

methods:

Two series of amphiphilic polymer micelles, PEG-b-PCLm and PEG-b-PCLm/TPGS, were synthesized. Doxorubicin (DOX) loading into the micelles was achieved via solvent dialysis.

Results:

The micelles displayed excellent biocompatibility, narrow size distribution, and uniform morphology. DOX-loaded micelles exhibited enhanced antitumor efficacy and increased drug accumulation at tumor sites compared with free DOX. Additionally, 4A-PEG47-b-PCL21/TPGS micelles effectively suppressed drug-resistant MCF-7/ADR cells.

Conclusion:

This study introduces a novel micelle formulation with exceptional serum stability and efficacy against drug resistance, promising for cancer therapy. It highlights innovative strategies for refining clinical translation and ensuring sustained efficacy and safety in vivo.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polietilenoglicóis / Doxorrubicina / Resistencia a Medicamentos Antineoplásicos / Micelas Limite: Animals / Female / Humans Idioma: En Revista: Nanomedicine (Lond) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polietilenoglicóis / Doxorrubicina / Resistencia a Medicamentos Antineoplásicos / Micelas Limite: Animals / Female / Humans Idioma: En Revista: Nanomedicine (Lond) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido