Epigenetic modifications of gonadotropin receptors can regulate follicular development.
Anim Reprod Sci
; 268: 107534, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-39047429
ABSTRACT
The spatiotemporal transcription of follicle-stimulating hormone receptor (FSHR) and luteinizing hormone/human chorionic gonadotropin receptor (LHCGR) are crucial events for follicular development. However, their regulatory mechanisms are unclear. DNA methylation and histone acetylation are the main epigenetic modifications, and play important roles in transcriptional expression, which regulate cell responses including cell proliferation, senescence and apoptosis. This review will discuss the dynamic epigenetic modifications of FSHR and LHCGR that occur during the process of follicular development and their response to gonadotropins. In addition, some alteration patterns that occur during these epigenetic modifications, as well as their retrospect retrotransposons, which regulate the gene expression levels of FSHR and LHCGR will be discussed.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Epigênese Genética
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Anim Reprod Sci
Ano de publicação:
2024
Tipo de documento:
Article
País de publicação:
Holanda