Pd-catalyzed Suzuki-type cross-coupling of 2-pyridyl carbamoyl fluorides.

Jabbarpoor, Maryam; LeBlanc, Jesse; Chen, Zichuan; Cadwallader, Dusty; Le, Christine M

Jabbarpoor, Maryam; LeBlanc, Jesse; Chen, Zichuan; Cadwallader, Dusty; Le, Christine M.

Afiliação

Jabbarpoor M; Department of Chemistry, York University, 4700 Keele Street, Toronto, ON, M3J 1P3, Canada. cmle@yorku.ca.
LeBlanc J; Department of Chemistry, York University, 4700 Keele Street, Toronto, ON, M3J 1P3, Canada. cmle@yorku.ca.
Chen Z; Department of Chemistry, York University, 4700 Keele Street, Toronto, ON, M3J 1P3, Canada. cmle@yorku.ca.
Cadwallader D; Department of Chemistry, York University, 4700 Keele Street, Toronto, ON, M3J 1P3, Canada. cmle@yorku.ca.
Le CM; Department of Chemistry, York University, 4700 Keele Street, Toronto, ON, M3J 1P3, Canada. cmle@yorku.ca.

Chem Commun (Camb) ; 2024 Jul 26.

Article em En | MEDLINE | ID: mdl-39054900

ABSTRACT

ABSTRACT

We describe a palladium-catalyzed Suzuki-type cross-coupling reaction of 2-pyridyl carbamoyl fluorides with boronic acids, which provides entry to medicinally relevant pyridyl amides. Mechanistic studies, including the synthesis and reactivity of carbamoyl Pd-F complexes, reveal the importance of both the fluoride electrophile and nitrogen directing group for aiding reactivity.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Canadá

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