Breslow density ability to predict melanoma survival: should it be used in clinical practice?
Clin Exp Dermatol
; 2024 Jul 27.
Article
em En
| MEDLINE
| ID: mdl-39067054
ABSTRACT
BACKGROUND:
Breslow density (BD) is an estimation of melanoma volume, which has emerged as a novel histopathological prognostic biomarker.OBJECTIVES:
Our aim was to evaluate the role of BD as predictor of patients´ survival and assess its prognostic value in relation to overall survival (OS), disease-free survival (DFS), melanoma-specific survival (MSS) and metastasis-free survival (MFS).METHODS:
A retrospective observational study in a cohort of 107 patients with invasive melanoma was conducted. Kaplan-Meier and Log-rank tests were used for 10-year survival analysis. The ability of BD and Breslow thickness (BT) to predict survival was assessed using receiver operating characteristic curves.RESULTS:
The average follow-up was 115 months excluding deaths. BD ≥65% showed lower survival rates compared with the BD<65% group (log-rank test p<0.001). Area under the curve (AUC) of BD ≥65% was higher than BT's for all studied survival rates except for melanoma-specific survival, in which absolute BD showed the highest value.CONCLUSIONS:
BD is proposed as a simple, valuable and inexpensive histopathological feature that could provide with valuable information to current melanoma staging, since it has proved a statistically significant prognostic value in relation to survival in melanoma patients, and comparable 10-year survival prediction ability to BT.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Clin Exp Dermatol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Espanha