Your browser doesn't support javascript.
loading
The Efficacy of Risk Factor Modification Compared to NAD+ Repletion in Diastolic Heart Failure.
Koay, Yen Chin; Liu, Ren Ping; McIntosh, Bailey; Vigder, Niv; Lauren, Serlin; Bai, Angela Yu; Tomita, Saki; Li, Desmond; Harney, Dylan; Hunter, Benjamin; Zhang, Yunwei; Yang, Jean; Bannon, Paul; Philp, Ashleigh; Philp, Andrew; Kaye, David M; Larance, Mark; Lal, Sean; O'Sullivan, John F.
Afiliação
  • Koay YC; Cardiometabolic Medicine Group, The University of Sydney, Sydney, New South Wales, Australia.
  • Liu RP; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
  • McIntosh B; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Vigder N; Cardiometabolic Medicine Group, The University of Sydney, Sydney, New South Wales, Australia.
  • Lauren S; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
  • Bai AY; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Tomita S; Cardiometabolic Medicine Group, The University of Sydney, Sydney, New South Wales, Australia.
  • Li D; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
  • Harney D; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Hunter B; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
  • Zhang Y; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Yang J; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, New South Wales, Australia.
  • Bannon P; Cardiometabolic Medicine Group, The University of Sydney, Sydney, New South Wales, Australia.
  • Philp A; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
  • Philp A; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Kaye DM; Cardiometabolic Medicine Group, The University of Sydney, Sydney, New South Wales, Australia.
  • Larance M; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Lal S; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, New South Wales, Australia.
  • O'Sullivan JF; Cardiometabolic Medicine Group, The University of Sydney, Sydney, New South Wales, Australia.
JACC Basic Transl Sci ; 9(6): 733-750, 2024 Jun.
Article em En | MEDLINE | ID: mdl-39070276
ABSTRACT
Heart failure (HF) with left ventricular diastolic dysfunction is a growing global concern. This study evaluated myocardial oxidized nicotinamide adenine dinucleotide (NAD+) levels in human systolic and diastolic HF and in a murine model of HF with preserved ejection fraction, exploring NAD+ repletion as therapy. We quantified myocardial NAD+ and nicotinamide phosphoribosyltransferase levels, assessing restoration with nicotinamide riboside (NR). Findings show significant NAD+ and nicotinamide phosphoribosyltransferase depletion in human diastolic HF myocardium, but NR successfully restored NAD+ levels. In murine HF with preserved ejection fraction, NR as preventive and therapeutic intervention improved metabolic and antioxidant profiles. This study underscores NAD+ repletion's potential in diastolic HF management.
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Austrália País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Austrália País de publicação: Estados Unidos