Your browser doesn't support javascript.
loading
Smoking reduction using an electronic nicotine delivery system (ENDS) with nicotine delivery similar to combustible cigarettes.
Rose, Jed E; Behm, Frederique M; Cohen, Gal; Willette, Perry N; Botts, Tanaia L; Botts, David R.
Afiliação
  • Rose JE; Rose Research Center, LLC, 7240 ACC Blvd, Raleigh, NC, 27617, USA. jed.rose@roseresearchcenter.com.
  • Behm FM; Rose Research Center, LLC, 7240 ACC Blvd, Raleigh, NC, 27617, USA.
  • Cohen G; Rose Research Center, LLC, 7240 ACC Blvd, Raleigh, NC, 27617, USA.
  • Willette PN; Rose Research Center, LLC, 7240 ACC Blvd, Raleigh, NC, 27617, USA.
  • Botts TL; Rose Research Center, LLC, 7240 ACC Blvd, Raleigh, NC, 27617, USA.
  • Botts DR; Rose Research Center, LLC, 7240 ACC Blvd, Raleigh, NC, 27617, USA.
Harm Reduct J ; 21(1): 142, 2024 Jul 29.
Article em En | MEDLINE | ID: mdl-39075535
ABSTRACT

BACKGROUND:

Electronic nicotine delivery systems (ENDS) offer a promising approach to tobacco harm reduction, but many people use both ENDS and combustible cigarettes ("dual use"), which undermines potential risk reduction. To explore the role of ENDS nicotine delivery in promoting switching to ENDS, we conducted a study in which people who smoked cigarettes were offered an ENDS that had previously been shown to replicate the rapid nicotine pharmacokinetics of combustible cigarettes (BIDI® Stick).

METHODS:

Twenty-five cigarette smoking adults, not seeking smoking cessation treatment, but open to using ENDS as a cigarette substitute, were provided with a 12-week supply of BIDI® Stick in tobacco or menthol flavors, during a study that included seven biweekly sessions and a 6-month follow-up. Daily diaries assessed ENDS and cigarette use, and exhaled carbon monoxide (eCO) served as an objective marker of smoke intake. Subjective ratings were collected to assess the rewarding properties of ENDS and combustible cigarettes, and indices of nicotine dependence.

RESULTS:

Over 12 weeks, ENDS use increased to an average of 15.8 occasions per day (SD = 20.2) and self-reported cigarette consumption decreased by 82% from 16.7 cigarettes/day (SD = 6.0) at baseline to 3.0 cigarettes/day (SD = 4.1) at week 12. The eCO level decreased by 27% from an average of 20.0 ppm (SD = 9.8) at baseline to 14.5 ppm (SD = 9.9) at week 12. Four of 25 participants completely switched to ENDS and were smoking abstinent during weeks 9-12. At 6 months one participant was confirmed to be abstinent. Ratings of subjective reward for the ENDS were very similar to those of participants' usual brands of cigarettes. Dependence level was lower for the ENDS than for combustible cigarettes.

CONCLUSIONS:

In this study, the ENDS effectively replicated the subjective rewarding effects of participants' usual brands of cigarettes and led to a substantial reduction in reported cigarettes/day. Exhaled CO showed less of a decrease, possibly due to compensatory smoking behavior and/or the timing of eCO measurements that might not have reflected smoke intake throughout the day. The relatively low rate of sustained smoking abstinence at 6 months suggests that additional approaches continue to be needed for achieving higher rates of complete switching. TRIAL REGISTRATION ClinicalTrials.gov identifier NCT05855343.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistemas Eletrônicos de Liberação de Nicotina / Redução do Consumo de Tabaco / Nicotina Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Harm Reduct J Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistemas Eletrônicos de Liberação de Nicotina / Redução do Consumo de Tabaco / Nicotina Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Harm Reduct J Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos