Expanding the toolbox of Baeyer-Villiger and flavin monooxygenase biocatalysts for the enantiodivergent green synthesis of sulfoxides.
Green Chem
; 26(15): 8685-8693, 2024 Jul 29.
Article
em En
| MEDLINE
| ID: mdl-39081496
ABSTRACT
Two new monooxygenase biocatalysts, the Baeyer-Villiger monooxygenase BVMO145 and the flavin monooxygenase FMO401 from Almac library, have been found to catalyse the enantiodivergent oxidation of sulfides bearing N-heterocyclic substituents into sulfoxides under mild and green conditions. The biocatalyst BVMO145 provides (S)-sulfoxides while the flavin monooxygenase FMO401 affords (R)-sulfoxides with good conversions and high ee.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Green Chem
Ano de publicação:
2024
Tipo de documento:
Article