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Transformation of a Benign Adrenocortical Adenoma to a Metastatic Adrenocortical Carcinoma Is Rare But It Happens.
Angelousi, Anna; Jouinot, Anne; Bourgioti, Charis; Tokmakidis, Panagiotis; Bertherat, Jérôme; Kaltsas, Gregory.
Afiliação
  • Angelousi A; First Department of Internal Medicine, Unit of Endocrinology, Laikon Hospital, Center of Excellence of Endocrine Tumours, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  • Jouinot A; Université de Paris, Institut Cochin, Department of Endocrinology, Referral Center for Rare Adrenal Diseases, INSERM U-1016, CNRS UMR- 8104, 75014 Paris, France.
  • Bourgioti C; Department of Radiology, School of Medicine, National and Kapodistrian University of Athens, Aretaieion Hospital, 11528 Athens, Greece.
  • Tokmakidis P; Neuroendocrine Tumor Unit, ENETS Centre of Excellence, 1st Department of Propaedeutic and Internal Medicine, Laiko Hospital, National and Kapodistrian University of Athens, 11527, Athens, Greece.
  • Bertherat J; Université de Paris, Institut Cochin, Department of Endocrinology, Referral Center for Rare Adrenal Diseases, INSERM U-1016, CNRS UMR- 8104, 75014 Paris, France.
  • Kaltsas G; Neuroendocrine Tumor Unit, ENETS Centre of Excellence, 1st Department of Propaedeutic and Internal Medicine, Laiko Hospital, National and Kapodistrian University of Athens, 11527, Athens, Greece.
JCEM Case Rep ; 2(8): luae131, 2024 Aug.
Article em En | MEDLINE | ID: mdl-39081696
ABSTRACT
The transformation of an adrenocortical adenoma (ACA) to an adrenocortical carcinoma (ACC) is extremely rare. Current guidelines suggest against further imaging studies and follow-up in patients with nonfunctional adrenal incidentalomas (NFAIs) with benign imaging characteristics. Herein, we present a 64-year-old male patient diagnosed initially with a NFAI of 3 cm in size with imaging characteristics consistent with an ACA. However, 13 years after initial diagnosis, this apparent ACA developed into a high-grade cortisol and androgen-secreting ACC with synchronous metastases. The literature review revealed a further 9 case reports of adrenal incidentalomas initially characterized as ACA that subsequently developed into ACC within a period ranging from 1 to 10 years. The pathogenesis of transformation of an initially denoted ACA to ACC is not fully delineated, although the existing literature focuses on the preexisting or changing genetic background of these lesions, highlighting the need to develop robust prognostic markers to identify patients at risk and individualize the follow-up of these unique cases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JCEM Case Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Grécia País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JCEM Case Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Grécia País de publicação: Reino Unido