Bivalent target-binding bioPROTACs induce potent degradation of oncogenic SHP2.

Hoffman, Megan; Krum, David; Wittrup, K Dane

Hoffman, Megan; Krum, David; Wittrup, K Dane.

Afiliação

Hoffman M; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Krum D; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Wittrup KD; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. Electronic address: wittrup@mit.edu.

J Biol Chem ; 300(9): 107616, 2024 Jul 31.

Article em En | MEDLINE | ID: mdl-39089586

Palavras-chave

BioPROTAC; E3 ubiquitin ligase; PROTAC; SHP2; SPOP; cancer; proteasome; protein degradation; protein engineering; targeted protein degradation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Biol Chem Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

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