Congenital and acquired hypothyroidism: temporal and spatial trends in France from 2014 to 2019.

ABSTRACT

PURPOSE: To assess the incidence of congenital hypothyroidism (CH) and acquired hypothyroidism (AH) between 2014 and 2019 in continental France. METHODS: New cases of CH and AH were identified using the French National Health Data System (Système Nationale des Données de Santé, SNDS). Temporal trends were studied using linear regression models. Spatial distributions were studied using Moran's global index (I) and the statistical method and local indicators of spatial association. RESULTS: The incidence of permanent CH in females increased by 8.9% per year (2014 36.9 [31.1-43.7] per 100,000 birth-years vs. 2019 51 [43.9-59.3] per 100,000 birth-years, p < 0.01). The incidence of AH decreased between 2014 and 2019 for both females (2014 535.7 [533.2-538.2] per 100,000 person-years vs 2019 335.5 [333.6-337.4] per 100,000 person-years, p < 0.01) and males (2014 197.5 [195.9-199] per 100,000 person-years vs 2019 141.7 [140.4-142.9] per 100,000 person-years, p<0.01). The incidence of hypothyroidism was high in the Nord-Pas-De-Calais and Lorraine regions (CH and AH). CONCLUSIONS: The incidence of permanent CH in females has increased over time. AH incidence decreased. It seems necessary to investigate environmental factors in the disparity of incidence distribution.