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HLA-DM and HLA-DO interplay for the peptide editing of HLA class II in healthy tissues and leukemia.
Budeus, Bettina; Álvaro-Benito, Miguel; Crivello, Pietro.
Afiliação
  • Budeus B; Institute of Cell Biology (Cancer Research), Medical Faculty, University of Duisburg-Essen, Essen, Germany. Electronic address: Bettina.Budeus@uk-essen.de.
  • Álvaro-Benito M; School of Medicine, Universidad Complutense de Madrid, 12 de Octubre Health Research Institute, Madrid, Spain; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany. Electronic address: migalv07@ucm.es.
  • Crivello P; Institute for Experimental Cellular Therapy, University Hospital Essen, Essen, Germany. Electronic address: pietro.crivello@uk-essen.de.
Best Pract Res Clin Haematol ; 37(2): 101561, 2024 Jun.
Article em En | MEDLINE | ID: mdl-39098801
ABSTRACT
HLA class II antigen presentation is modulated by the activity of the peptide editor HLA-DM and its antagonist HLA-DO, with their interplay controlling the peptide repertoires presented by normal and malignant cells. The role of these molecules in allogeneic hematopoietic cell transplantation (alloHCT) is poorly investigated. Balanced expression of HLA-DM and HLA-DO can influence the presentation of leukemia-associated antigens and peptides targeted by alloreactive T cells, therefore affecting both anti-leukemia immunity and the potential onset of Graft versus Host Disease. We leveraged on a large collection of bulk and single cell RNA sequencing data, available at different repositories, to comprehensively review the level and distribution of HLA-DM and HLA-DO in different cell types and tissues of the human body. The resulting expression atlas will help future investigations aiming to dissect the dual role of HLA class II peptide editing in alloHCT, and their potential impact on its clinical outcome.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia / Antígenos HLA-D Limite: Humans Idioma: En Revista: Best Pract Res Clin Haematol Assunto da revista: HEMATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de publicação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia / Antígenos HLA-D Limite: Humans Idioma: En Revista: Best Pract Res Clin Haematol Assunto da revista: HEMATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de publicação: Holanda