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Seronegative celiac disease with transient protein-losing enteropathy and vitamin B12 deficiency in a pediatric patient: Case report.
Shaikh, Aisha; Ashraf, Saad; Ansari, Muhammad Ahsan; Zain-Ul-Haq, Muhammad; Hashim, Hashim Talib; Hashim, Ali Talib; Alhatemi, Ahmed Qasim Mohammed.
Afiliação
  • Shaikh A; Department of Pediatrics Civil Hospital Karachi, Dow University of Health Sciences Karachi Pakistan.
  • Ashraf S; Department of Medicine Dow University of Health Sciences Karachi Pakistan.
  • Ansari MA; Department of Medicine Dow University of Health Sciences Karachi Pakistan.
  • Zain-Ul-Haq M; Department of Medicine Dow University of Health Sciences Karachi Pakistan.
  • Hashim HT; College of Medicine Warith Al Anbiyaa University Karbala Iraq.
  • Hashim AT; Golestan University of Medical Sciences Gorgan Iran.
  • Alhatemi AQM; Department of Internal Medicine Al Nasiriyah Teaching Hospital Thi Qar Iraq.
Clin Case Rep ; 12(8): e9297, 2024 Aug.
Article em En | MEDLINE | ID: mdl-39114851
ABSTRACT
Key Clinical Message Early recognition and management of seronegative celiac disease, even in the absence of typical serological markers, can prevent complications and ensure better health outcomes in pediatric patients. Consideration of a gluten-free diet in similar cases can lead to significant clinical improvement. Abstract Celiac disease, characterized by its diverse clinical manifestations, often necessitates adherence to a gluten-free diet, particularly in pediatric patients for optimal growth and development. This report presents the case of an 11-year-old male who exhibited recurrent symptoms of fever and diarrhea progressing to edema and pallor, with a history dating back to age 3. Laboratory findings revealed pancytopenia, hypoalbuminemia, and proteinuria. Despite negative serological markers, noninvasive tests, along with clinical improvement on a gluten-free diet and supportive measures within a month, suggested celiac disease complicated by transient protein-losing enteropathy and vitamin B12 deficiency. It is important to note that other malabsorption disorders can also show clinical improvement following a gluten-free diet. Additionally, the antibiotic treatment received by the patient could have addressed other possible causes of malabsorption, complicating the differential diagnosis. This case highlights the importance of early recognition and management of celiac disease, especially in pediatric patients, to prevent complications and promote optimal health outcomes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Clin Case Rep Ano de publicação: 2024 Tipo de documento: Article País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Clin Case Rep Ano de publicação: 2024 Tipo de documento: Article País de publicação: Reino Unido