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Senescence in Adipose-Derived Stem Cells: Biological Mechanisms and Therapeutic Challenges.
Foti, Riccardo; Storti, Gabriele; Palmesano, Marco; Scioli, Maria Giovanna; Fiorelli, Elena; Terriaca, Sonia; Cervelli, Giulio; Kim, Bong Sung; Orlandi, Augusto; Cervelli, Valerio.
Afiliação
  • Foti R; Plastic Surgery, Department of Surgical Sciences, University of Rome "Tor Vergata", 00133 Rome, Italy.
  • Storti G; Plastic Surgery, Department of Surgical Sciences, University of Rome "Tor Vergata", 00133 Rome, Italy.
  • Palmesano M; Plastic Surgery, Department of Surgical Sciences, University of Rome "Tor Vergata", 00133 Rome, Italy.
  • Scioli MG; Anatomy Pathology Institute, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", 00133 Rome, Italy.
  • Fiorelli E; Anatomy Pathology Institute, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", 00133 Rome, Italy.
  • Terriaca S; Anatomy Pathology Institute, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", 00133 Rome, Italy.
  • Cervelli G; Department of Experimental Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
  • Kim BS; Department of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8006 Zurich, Switzerland.
  • Orlandi A; Anatomy Pathology Institute, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", 00133 Rome, Italy.
  • Cervelli V; Plastic Surgery, Department of Surgical Sciences, University of Rome "Tor Vergata", 00133 Rome, Italy.
Int J Mol Sci ; 25(15)2024 Aug 01.
Article em En | MEDLINE | ID: mdl-39125960
ABSTRACT
Adipose tissue-derived stem cells (ADSCs) represent a subset of the mesenchymal stem cells in every adipose compartment throughout the body. ADSCs can differentiate into various cell types, including chondrocytes, osteocytes, myocytes, and adipocytes. Moreover, they exhibit a notable potential to differentiate in vitro into cells from other germinal lineages, including endothelial cells and neurons. ADSCs have a wide range of clinical applications, from breast surgery to chronic wounds. Furthermore, they are a promising cell population for future tissue-engineering uses. Accumulating evidence indicates a decreased proliferation and differentiation potential of ADSCs with an increasing age, increasing body mass index, diabetes mellitus, metabolic syndrome, or exposure to radiotherapy. Therefore, the recent literature thoroughly investigates this cell population's senescence mechanisms and how they can hinder its possible therapeutic applications. This review will discuss the biological mechanisms and the physio-pathological causes behind ADSC senescence and how they can impact cellular functionality. Moreover, we will examine the possible strategies to invert these processes, re-establishing the full regenerative potential of this progenitor population.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diferenciação Celular / Tecido Adiposo / Senescência Celular / Células-Tronco Mesenquimais Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diferenciação Celular / Tecido Adiposo / Senescência Celular / Células-Tronco Mesenquimais Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Itália