Predictive value of number of metastatic lymph nodes and lymph node ratio for prognosis of patients with FIGO 2018 stage IIICp cervical cancer: a multi-center retrospective study.
BMC Cancer
; 24(1): 1005, 2024 Aug 13.
Article
em En
| MEDLINE
| ID: mdl-39138415
ABSTRACT
BACKGROUND:
To identify the cut-off values for the number of metastatic lymph nodes (nMLN) and lymph node ratio (LNR) that can predict outcomes in patients with FIGO 2018 IIICp cervical cancer (CC).METHODS:
Patients with CC who underwent radical hysterectomy with pelvic lymphadenectomy were identified for a propensity score-matched (PSM) cohort study. A receiver operating characteristic (ROC) curve analysis was performed to determine the critical nMLN and LNR values. Five-year overall survival (OS) and disease-free survival (DFS) rates were compared using Kaplan-Meier and Cox proportional hazard regression analyses.RESULTS:
This study included 3,135 CC patients with stage FIGO 2018 IIICp from 47 Chinese hospitals between 2004 and 2018. Based on ROC curve analysis, the cut-off values for nMLN and LNR were 3.5 and 0.11, respectively. The final cohort consisted of nMLN ≤ 3 (n = 2,378) and nMLN > 3 (n = 757) groups and LNR ≤ 0.11 (n = 1,748) and LNR > 0.11 (n = 1,387) groups. Significant differences were found in survival between the nMLN ≤ 3 vs the nMLN > 3 (post-PSM, OS 76.8% vs 67.9%, P = 0.003; hazard ratio [HR] 1.411, 95% confidence interval [CI] 1.108-1.798, P = 0.005; DFS 65.5% vs 55.3%, P < 0.001; HR 1.428, 95% CI 1.175-1.735, P < 0.001), and the LNR ≤ 0.11 and LNR > 0.11 (post-PSM, OS 82.5% vs 76.9%, P = 0.010; HR 1.407, 95% CI 1.103-1.794, P = 0.006; DFS 72.8% vs 65.1%, P = 0.002; HR 1.347, 95% CI 1.110-1.633, P = 0.002) groups.CONCLUSIONS:
This study found that nMLN > 3 and LNR > 0.11 were associated with poor prognosis in CC patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias do Colo do Útero
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Excisão de Linfonodo
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Linfonodos
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Metástase Linfática
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Estadiamento de Neoplasias
Limite:
Adult
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Aged
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
BMC Cancer
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China
País de publicação:
Reino Unido