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Herpes zoster and long-term risk of subjective cognitive decline.
Yeh, Tian-Shin; Curhan, Gary C; Yawn, Barbara P; Willett, Walter C; Curhan, Sharon G.
Afiliação
  • Yeh TS; Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, No.250, Wuxing St, Taipei, 11031, Taiwan. tianshin.yeh@gmail.com.
  • Curhan GC; Department of Physical Medicine and Rehabilitation, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. tianshin.yeh@gmail.com.
  • Yawn BP; Department of Epidemiology and Nutrition, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA. tianshin.yeh@gmail.com.
  • Willett WC; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. tianshin.yeh@gmail.com.
  • Curhan SG; Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan. tianshin.yeh@gmail.com.
Alzheimers Res Ther ; 16(1): 180, 2024 Aug 14.
Article em En | MEDLINE | ID: mdl-39138535
ABSTRACT

BACKGROUND:

Herpes zoster (HZ), commonly known as "shingles," may contribute to cognitive decline through mechanisms such as neuroinflammation or direct neuronal injury. However, evidence on the longitudinal association between HZ and cognitive decline is conflicting and whether the risk differs by APOE ε4-carrier status has not been studied; prospective cohort studies on the association between HZ vaccination and cognitive decline are also lacking.

METHODS:

We included 149,327 participants from three large cohorts-the Nurses' Health Study (NHS), NHSII, and Health Professionals Follow-Up Study (HPFS)-to prospectively examine the association between HZ and subsequent subjective cognitive decline (SCD). Poisson regression was used to estimate the multivariable-adjusted relative risk (MVRR) of a 3-unit increment in SCD score according to years since HZ compared with participants with no history of HZ.

RESULTS:

Compared with individuals with no history of HZ, the MVRR (95% CI) of a 3-unit increment in SCD score was significantly and independently higher among individuals with a history of HZ, but the duration of time since HZ when the elevated risk of SCD was statistically significant differed among the cohorts. In NHS, HZ was associated with higher long-term risk of SCD; compared with individuals with no history of HZ, the MVRR (95% CI) of a 3-unit increment in SCD score was 1.14 (1.01, 1.32) for ≥ 13 years since HZ. In NHS II, HZ was associated with higher risk of SCD in both the short-term [MVRR 1.34 (1.18, 1.53) for 1-4 years] and long-term [MVRR 1.20 (1.08, 1.34) for ≥ 13 years since HZ]. In HPFS, an elevated risk of SCD was suggested across all time points. Among the subset of participants with information on APOE ε4, there was a suggestion that the association differed by APOE ε4 carrier status, but the results were not consistent between women and men. Among the subset of women with information on HZ vaccination, there was a suggestion that the long-term risk of SCD may be greater among women who were not vaccinated against HZ.

CONCLUSIONS:

Data from three large independent cohorts of women and men showed that HZ was associated with higher long-term risk of SCD, and the risk may differ by APOE ε4-carrier status.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Disfunção Cognitiva / Herpes Zoster Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Alzheimers Res Ther Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Taiwan País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Disfunção Cognitiva / Herpes Zoster Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Alzheimers Res Ther Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Taiwan País de publicação: Reino Unido