Ag+-Induced Supramolecular Polymers of Folic Acid: Reinforced by External Kosmotropic Anions Exhibiting Salting Out.
Biomacromolecules
; 25(9): 6203-6215, 2024 Sep 09.
Article
em En
| MEDLINE
| ID: mdl-39153217
ABSTRACT
Introducing kosmotropic salts enhances protein stability and reduces solubility by withdrawing water from the protein surface, leading to 'salting out', a phenomenon we have mimicked in supramolecular polymers (SPs). Under the guidance of Ag+, folic acid (FA) self-assembled in water through slipped-stacking and hydrophobic interactions into elongated, robust one-dimensional SPs, resulting in thermo-stable supergels. The SPs exhibited temperature and dilution tolerance, attributed to the stability of the FA-Ag+ complex and its hydrophobic stacking. Importantly, FA-Ag+ SP's stability has been augmented by the kosmotropic anions, such as SO42-, strengthening hydrophobic interactions in the SP, evident from the enhanced J-band, causing improvement of gel's mechanical property. Interestingly, higher kosmotrope concentrations caused a significant decrease in SP's solubility, leading to precipitation of the reinforced SPsâa 'salting out' effect. Conversely, chaotropes like ClO4- slightly destabilized hydrophobic stacking and promoted an extended conformation of individual SP chain with enhanced solubility, resembling a 'salting in' effect.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polímeros
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Prata
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Solubilidade
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Interações Hidrofóbicas e Hidrofílicas
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Ácido Fólico
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Ânions
Idioma:
En
Revista:
Biomacromolecules
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Índia
País de publicação:
Estados Unidos