Exploring the causal relationship between psoriasis and osteoarthritis through a 2-sample Mendelian randomization study.
Medicine (Baltimore)
; 103(33): e39303, 2024 Aug 16.
Article
em En
| MEDLINE
| ID: mdl-39159244
ABSTRACT
Previous research has demonstrated a robust association between osteoarthritis (OA) and psoriasis. Notably, a significant proportion of psoriasis patients exhibit symptoms of arthritis, particularly psoriatic arthritis. However, a definitive causal relationship between psoriasis, psoriatic arthritis and OA remains to be established. This study aimed to elucidate the causal relationship between psoriasis, psoriatic arthritis, and osteoarthritis using a 2-sample Mendelian randomization approach. The causal relationship between psoriasis, psoriatic arthritis and OA was rigorously investigated using a 2-sample Mendelian Randomization (MR) approach. Instrumental variables pertinent to psoriasis, psoriatic arthritis and 4 distinct types of OA (knee osteoarthritis (KOA), hand osteoarthritis (HOA), total knee replacement (TKR), and total hip replacement (THR)) were sourced from extensive, published genome-wide association studies (GWAS). To estimate the causal effects, methodologies such as inverse variance weighting (IVW), MR-Egger, and weighted median estimation (WM) were employed. Mendelian Randomization analysis suggested a potential causal effect of psoriasis on osteoarthritis (OA). For hand OA (HOA), the P value was .381 (ORâ
=â
0.28); for knee OA (KOA), the P value was .725 (ORâ
=â
1.46); for TKR, the P value was .488 (ORâ
=â
0.274); and for THR, the P value was .454 (ORâ
=â
0.216). Furthermore, we explored the causality of psoriatic arthritis on OA. For HOA, the P value was .478 (ORâ
=â
0.0095); for KOA, the P value was .835 (ORâ
=â
0.345); for THR, the P value was .807 (ORâ
=â
0.120); and for TKR, the P value was .860 (ORâ
=â
0.190). Our findings indicate that there is no evidence of a causal connection between psoriasis or psoriatic arthritis and OA, suggesting that while psoriasis may contribute to arthritis, it does not influence OA development.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoartrite
/
Psoríase
/
Artrite Psoriásica
/
Estudo de Associação Genômica Ampla
/
Análise da Randomização Mendeliana
Limite:
Humans
Idioma:
En
Revista:
Medicine (Baltimore)
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China
País de publicação:
Estados Unidos