The causal effect of gut microbiota on hepatic encephalopathy: a mendelian randomization analysis.
BMC Med Genomics
; 17(1): 216, 2024 Aug 19.
Article
em En
| MEDLINE
| ID: mdl-39160503
ABSTRACT
BACKGROUND:
There is growing evidence for a relationship between gut microbiota and hepatic encephalopathy (HE). However, the causal nature of the relationship between gut microbiota and HE has not been thoroughly investigated.METHOD:
This study utilized the large-scale genome-wide association studies (GWAS) summary statistics to evaluate the causal association between gut microbiota and HE risk. Specifically, two-sample Mendelian randomization (MR) approach was used to identify the causal microbial taxa for HE. The inverse variance weighted (IVW) method was used as the primary MR analysis. Sensitive analyses were performed to validate the robustness of the results.RESULTS:
The IVW method revealed that the genus Bifidobacterium (OR = 0.363, 95% CI 0.139-0.943, P = 0.037), the family Bifidobacteriaceae (OR = 0.359, 95% CI 0.133-0.950, P = 0.039), and the order Bifidobacteriales (OR = 0.359, 95% CI 0.133-0.950, P = 0.039) were negatively associated with HE. However, no causal relationship was observed among them after the Bonferroni correction test. Neither heterogeneity nor horizontal pleiotropy was found in the sensitivity analysis.CONCLUSION:
Our MR study demonstrated a potential causal association between Bifidobacterium, Bifidobacteriaceae, and Bifidobacteriales and HE. This finding may provide new therapeutic targets for patients at risk of HE in the future.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encefalopatia Hepática
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Estudo de Associação Genômica Ampla
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Análise da Randomização Mendeliana
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Microbioma Gastrointestinal
Limite:
Humans
Idioma:
En
Revista:
BMC Med Genomics
Assunto da revista:
GENETICA MEDICA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China
País de publicação:
Reino Unido