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Study the local metabolic changes of aneurysms through microcatheter sampling.
Li, Zejin; Zhang, Tingbao; Feng, Yu; Ma, Yihui; Chen, Hao; Wu, Xiaolin; Chen, Jiayi; Dai, Xuan; Chen, Jincao; Li, Xiang; Wei, Wei; Zhao, Wenyuan.
Afiliação
  • Li Z; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
  • Zhang T; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
  • Feng Y; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
  • Ma Y; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
  • Chen H; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
  • Wu X; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
  • Chen J; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
  • Dai X; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
  • Chen J; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
  • Li X; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
  • Wei W; Brain Research Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
  • Zhao W; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. wei.wei@whu.edu.cn.
Sci Rep ; 14(1): 19552, 2024 08 22.
Article em En | MEDLINE | ID: mdl-39174658
ABSTRACT
Intracranial aneurysm is the primary cause of nontraumatic subarachnoid hemorrhage. To assess aneurysm metabolism, we present a method of intra-operatively collecting blood samples from the aneurysm neck, as well as the proximal and distal responsible vessels, using microcatheters. Through these paired comparisons, we can eliminate the interpatient variation usually observed in plasma samples taken from the peripheral vein. We utilized 39 plasma samples from 13 intracranial patients to characterize the metabolite profiles using untargeted liquid chromatography-mass spectrometry. Our findings revealed that L-tyrosine is upregulated at relatively high levels at the aneurysm neck than the proximal and distal aneurysm, whereas phenylpyruvic acid, L-cystine, and L-ornithine are downregulated. Based on this, there was also a significant decrease in arginine within small aneurysm of the internal carotid artery. The 6-month follow-up indicated that patients who experienced good recovery had lower levels of biliverdin, bilirubin, and metabolites of coenzyme Q within the aneurysm. In conclusion, our investigation provides a comprehensive overview of plasma metabolites in patients with intracranial aneurysms, shedding light on potential pathogenetic mechanisms in unruptured intracranial aneurysms. Moreover, the study proposes innovative ideas for establishing postoperative follow-up timelines for flow diverter devices.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aneurisma Intracraniano Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aneurisma Intracraniano Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido