[Possibilities of magnetic resonance morphometry and laboratory biomarkers in studying the progression of multiple sclerosis]. / Vozmozhnosti magnitno-rezonansnoi morfometrii i laboratornykh biomarkerov v izuchenii progressirovaniya rasseyannogo skleroza.
Zh Nevrol Psikhiatr Im S S Korsakova
; 124(7. Vyp. 2): 66-71, 2024.
Article
em Ru
| MEDLINE
| ID: mdl-39175242
ABSTRACT
OBJECTIVE:
To show that magnetic resonance morphometry and laboratory biomarkers are promising methods for early detection of progressive forms of multiple sclerosis (MS). MATERIAL ANDMETHODS:
Eighty-one patients with MS were examined, magnetic resonance morphometry was performed in all of them, 60 patients were analyzed for neurofilament light chains (sNFL), phosphorylated neurofilament heavy chains (spNFH) and glial fibrillary protein (sGFAP) in serum by enzyme-linked immunosorbent assay.RESULTS:
Brain volumes were negatively correlated with disease duration, EDSS score, 25-foot walk test score and 9-ring test and positively correlated with the Symbol-Numeric Test and the Montreal Cognitive Assessment. Patients with progressive types of MS (PMS) had smaller volumes of brain gray matter, cerebellar white matter, occipital lobes, caudate nucleus, hippocampus, pallidum, thalamus, and contiguous nucleus. A CSF volume greater than 15.06% could suggest progression (CI 54.79-91%) with a sensitivity of 77.78% and specificity of 70.18%. When patients were on DMT, they had larger thalamic volumes (median 1.09% [1.6; 1.16] vs 1.04% [0.95; 1.14]; p=0.02) and smaller CSF volumes (13.86±2.87% vs. 15.55±3.49%; p=0.03). The levels of sNFL and spNFH were not increased in PMS and during exacerbations, and the low obtained values of sNFL suggest poor sensitivity of the method. There were trends (p=0.374) towards higher sGFAP in patients with PRS (median 3.2 ng/mL [1.85; 4.6] compared to remitting MS (2.05 ng/mL [1.29; 4.52]).CONCLUSION:
The results demonstrate the differences in brain volumes in patients with different types of MS and emphasize the importance of long-term follow-up to better assess disease progression.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Imageamento por Ressonância Magnética
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Biomarcadores
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Proteínas de Neurofilamentos
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Progressão da Doença
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Esclerose Múltipla
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
Ru
Revista:
Zh Nevrol Psikhiatr Im S S Korsakova
Assunto da revista:
NEUROLOGIA
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PSIQUIATRIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Federação Russa
País de publicação:
FEDERAÇÃO RUSSA
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RU
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RUSIA
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RUSSIA