Reward system activation improves recovery from acute myocardial infarction.
Nat Cardiovasc Res
; 3(7): 841-856, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-39196183
ABSTRACT
Psychological processes have a crucial role in the recovery from acute myocardial infarction (AMI), yet the underlying mechanisms of these effects remain elusive. Here we demonstrate the impact of the reward system, a brain network associated with motivation and positive expectations, on the clinical outcomes of AMI in mice. Chemogenetic activation of dopaminergic neurons in the reward system improved the remodeling processes and vascularization after AMI, leading to enhanced cardiac performance compared to controls. These effects were mediated through several physiological mechanisms, including alterations in immune activity and reduced adrenergic input to the liver. We further demonstrate an anatomical connection between the reward system and the liver, functionally manifested by altered transcription of complement component 3, which in turn affects vascularization and recovery from AMI. These findings establish a causal connection between a motivational brain network and recovery from AMI, introducing potential therapeutic avenues for intervention.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Recompensa
/
Recuperação de Função Fisiológica
/
Modelos Animais de Doenças
/
Camundongos Endogâmicos C57BL
/
Infarto do Miocárdio
Limite:
Animals
Idioma:
En
Revista:
Nat Cardiovasc Res
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Israel
País de publicação:
Reino Unido