Extracellular vesicles derived from mesenchymal stem cells suppress breast cancer progression by inhibiting angiogenesis.
Mol Med Rep
; 30(5)2024 11.
Article
em En
| MEDLINE
| ID: mdl-39219260
ABSTRACT
Previous studies have highlighted the antitumor effects of mesenchymal stem cellderived extracellular vesicles (MSCEVs), positioning them as a promising therapeutic avenue for cancer treatment. However, some researchers have proposed a bidirectional influence of MSCEVs on tumors, determined by the specific tissue origin of the MSCs and the types of tumors involved. The present study aimed to elucidate the effects of human placenta MSCderived extracellular vesicles (hPMSCEVs) on the malignant behavior of a mouse breast cancer model of 4T1 cells in vitro and in vivo. The findings revealed that hPMSCEVs significantly inhibited the proliferation, migration and colony formation of cultured 4T1 mouse breast cancer cells without inducing apoptosis. Exposure to conditioned medium from 4T1 cells pretreated with hPMSCEVs resulted in decreased angiogenic activity, accompanied by the downregulation of angiogenesispromoting genes in human umbilical vein endothelial cells. In murine xenograft models derived from the 4T1 cell line, local administration of hPMSCEVs substantially hindered tumor growth. Further results revealed that hPMSCEVs inhibited angiogenesis in vivo, as reflected by the use of a vascular growth factor receptor 2Fluc transgenic mouse model. In summary, the results confirmed that hPMSCEVs negatively modulated breast cancer growth by suppressing tumor cell proliferation and migration via an indirect antiangiogenic mechanism. These results underscored the therapeutic potential of EVs, suggesting a promising avenue for alternative anticancer treatments in the future.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
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Movimento Celular
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Proliferação de Células
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Células-Tronco Mesenquimais
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Células Endoteliais da Veia Umbilical Humana
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Vesículas Extracelulares
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Neovascularização Patológica
Limite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Mol Med Rep
Ano de publicação:
2024
Tipo de documento:
Article
País de publicação:
Grécia