Antitumor activities of antiCD44 monoclonal antibodies in mouse xenograft models of esophageal cancer.
Oncol Rep
; 52(5)2024 Nov.
Article
em En
| MEDLINE
| ID: mdl-39219278
ABSTRACT
CD44 is a type I transmembrane glycoprotein associated with poor prognosis in various solid tumors. Since CD44 plays a critical role in tumor development by regulating cell adhesion, survival, proliferation and stemness, it has been considered a target for tumor therapy. AntiCD44 monoclonal antibodies (mAbs) have been developed and applied to antibodydrug conjugates and chimeric antigen receptorT cell therapy. Anti-panCD44 mAbs, C44Mab5 and C44Mab46, which recognize both CD44 standard (CD44s) and variant isoforms were previously developed. The present study generated a mouse IgG2a version of the antipanCD44 mAbs (5mG2a and C44Mab46mG2a) to evaluate the antitumor activities against CD44positive cells. Both 5mG2a and C44Mab46mG2a recognized CD44soverexpressed CHOK1 (CHO/CD44s) cells and esophageal tumor cell line (KYSE770) in flow cytometry. Furthermore, both 5mG2a and C44Mab46mG2a could activate effector cells in the presence of CHO/CD44s cells and exhibited complement-dependent cytotoxicity against both CHO/CD44s and KYSE770 cells. Furthermore, the administration of 5mG2a and C44Mab46mG2a significantly suppressed CHO/CD44s and KYSE770 xenograft tumor development compared with the control mouse IgG2a. These results indicate that 5mG2a and C44Mab46mG2a could exert antitumor activities against CD44positive cancers and be a promising therapeutic regimen for tumors.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Esofágicas
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Cricetulus
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Receptores de Hialuronatos
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Ensaios Antitumorais Modelo de Xenoenxerto
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Anticorpos Monoclonais
Limite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Oncol Rep
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Japão
País de publicação:
Grécia