Lack of classical astroblastoma features in pediatric MN1::BEND2-fused brain tumors.

Chapman, Nicholas; Iqbal, Mohammed; Walker, Adam D; Hawes, Debra; Davidson, Tom Belle; Robison, Nathan; Tamrazi, Benita; Ji, Jianling; Krieger, Mark D; Cotter, Jennifer A

Chapman, Nicholas; Iqbal, Mohammed; Walker, Adam D; Hawes, Debra; Davidson, Tom Belle; Robison, Nathan; Tamrazi, Benita; Ji, Jianling; Krieger, Mark D; Cotter, Jennifer A.

Afiliação

Chapman N; Department of Surgery and Division of Neurosurgery, Children's Hospital Los Angeles, Los Angeles, California, USA.
Iqbal M; Department of Neurosurgery, University of Texas, Dell Medical School, Austin, Texas, USA.
Walker AD; Department of Pathology & Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA.
Hawes D; Department of Pathology & Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA.
Davidson TB; Keck School of Medicine, University of Southern California, Los Angeles, California, United States.
Robison N; Keck School of Medicine, University of Southern California, Los Angeles, California, United States.
Tamrazi B; Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, California, USA.
Ji J; Keck School of Medicine, University of Southern California, Los Angeles, California, United States.
Krieger MD; Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, California, USA.
Cotter JA; Keck School of Medicine, University of Southern California, Los Angeles, California, United States.

Brain Pathol ; : e13297, 2024 Sep 05.

Article em En | MEDLINE | ID: mdl-39237118

ABSTRACT

ABSTRACT

Three distinct MN1BEND2 fusion-positive tumors in pediatric patients. (A) Clinical course for each patient was variable in part due to differences in initial diagnosis. Each patient responded favorably to gross total resection and is stable at last follow-up. (B) Histologic diversity, lack of prominent classical astroblastoma features, and variable immunoexpression of key markers makes microscopic diagnosis challenging.

Palavras-chave

MN1::BEND2 fusion; MN1altered; RNA sequencing; astroblastoma; ependymoma; pediatric

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Brain Pathol Assunto da revista: CEREBRO / PATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Suíça

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google