Expanding the insect defensin landscape.

Adhikary, Krishnakoli; Poget, Sébastien F

Adhikary, Krishnakoli; Poget, Sébastien F.

Afiliação

Adhikary K; Department of Chemistry, College of Staten Island, City University of New York (CUNY), 2800 Victory Boulevard, Staten Island, NY 10314, USA; PhD Program in Chemistry, The Graduate Center, CUNY, 365 Fifth Avenue, New York, NY 10016, USA.
Poget SF; Department of Chemistry, College of Staten Island, City University of New York (CUNY), 2800 Victory Boulevard, Staten Island, NY 10314, USA; PhD Program in Chemistry, The Graduate Center, CUNY, 365 Fifth Avenue, New York, NY 10016, USA; PhD Program in Biochemistry, The Graduate Center, CUNY, 365 Fifth Avenue, New York, NY 10016, USA. Electronic address: sebastien.poget@csi.cuny.edu.

Structure ; 32(9): 1294-1296, 2024 Sep 05.

Article em En | MEDLINE | ID: mdl-39241760

ABSTRACT

ABSTRACT

In this issue of Structure, Walker et al.1 determined the NMR structure of a recently discovered defensin, Pp19, from the venom of an assassin bug. This peptide adopts an α-defensin-like structure, which had not been observed in insects before. Unlike mammalian α-defensins, which are generally antimicrobial, Pp19 has insecticidal activity.

Assuntos

Defensinas; Animais; Defensinas/química; Defensinas/metabolismo; Proteínas de Insetos/química; Proteínas de Insetos/metabolismo; alfa-Defensinas/química; alfa-Defensinas/metabolismo; Insetos/química; Insetos/metabolismo; Conformação Proteica; Inseticidas/química; Modelos Moleculares

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Defensinas Limite: Animals Idioma: En Revista: Structure Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

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