The toxic effect of lead exposure on the physiological homeostasis of grouper: Insight from gut-liver axis.
Mar Pollut Bull
; 207: 116926, 2024 Oct.
Article
em En
| MEDLINE
| ID: mdl-39244887
ABSTRACT
The heavy metal lead (Pb) pollution in marine environment has been widely concerned. The liver and intestine are important for the health of fish. In this study, the grouper were exposed to 1 µg/L Pb for 14 days, and the physiological homeostasis changes were explored via gut-liver axis. The results showed that Pb stress caused liver morphological changes, oxidative stress, and the accumulation and peroxidation of the lipids. The liver metabolism were disturbed, especially amino acid metabolism and the synthesis and degradation of ketone bodies. Pb stress also caused intestinal mucosal ablation, tight junction dysfunction and inflammatory response. Additionally, intestinal microbial diversity was decreased, and the community composition was altered especially several bacteria genera (Ruminococcus UCG-005, Ruminococcus UCG-014, Oscillibacter, and Streptococcus) were significantly correlated with the physiological indexes and metabolites of the liver. These results reveal that Pb stress negatively affect the physiological homeostasis of the grouper via gut-liver axis.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poluentes Químicos da Água
/
Microbioma Gastrointestinal
/
Homeostase
/
Chumbo
/
Fígado
Limite:
Animals
Idioma:
En
Revista:
Mar Pollut Bull
Ano de publicação:
2024
Tipo de documento:
Article
País de publicação:
Reino Unido