Reduction in halothane MAC: comparison of morphine and alfentanil.
Anesth Analg
; 64(8): 807-10, 1985 Aug.
Article
em En
| MEDLINE
| ID: mdl-3925818
ABSTRACT
The anesthetic potency and effectiveness of alfentanil and morphine were established by determining the effects of increasing drug doses on the alveolar anesthetic requirement of halothane to maintain a constant anesthetic (MAC) level. Six selected doses of alfentanil and four of morphine were administered to groups of mechanically ventilated rats anesthetized with halothane. Alfentanil was given as a loading dose followed by an intravenous infusion of 0.01-100 micrograms X kg-1 X min-1, and morphine was administered as a subcutaneous dose of 4-20 mg/kg. The reduction in halothane requirement after morphine was biphasic, with a rapid linear increase occurring up to an 8 mg/kg subcutaneous dose, followed by a further, slower reduction in halothane requirement after doses of 8-20 mg/kg. At a 20 mg/kg dose, the halothane MAC was reduced approximately 84%. With alfentanil, a curvilinear reduction in halothane MAC occurred up to an alfentanil dose of 15 micrograms X kg-1 X min-1, where a 48% reduction was found. Larger doses produced severe truncal, chest wall, and abdominal rigidity, precluding adequate ventilation and the determination of MAC.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fentanila
/
Halotano
/
Adjuvantes Anestésicos
/
Morfina
Limite:
Animals
Idioma:
En
Revista:
Anesth Analg
Ano de publicação:
1985
Tipo de documento:
Article