Abnormal expression of autophagy proteins in the duodenum of patients with functional dyspepsia: A preliminary study.
Arab J Gastroenterol
; 2024 Sep 14.
Article
em En
| MEDLINE
| ID: mdl-39278781
ABSTRACT
BACKGROUND AND STUDY AIMS:
Functional dyspepsia (FD) is a common disease with an unclear pathology. Autophagy is associated with inflammation and has been proposed to play a role in the development of FD. This study aimed to evaluate expression of the autophagy proteins beclin1 and p62/SQSTM1 in patients with FD. PATIENTS ANDMETHODS:
Duodenal mucosal tissues were collected from 10 patients with FD and 10 asymptomatic controls. The extent of autophagy was determined by examining expression levels of beclin1 and p62/SQSTM1 using quantitative polymerase chain reaction and immunohistochemistry techniques.RESULTS:
Lower expression levels of beclin1 protein were detected in the duodenal bulb (D1) and the second portion of the duodenum (D2) in patients with FD compared with asymptomatic controls. Higher levels of p62 protein were expressed in D1 in patients with FD than in controls. No differences in mRNA expression of beclin1 and p62 were observed between patients with FD and controls.CONCLUSION:
Abnormal autophagy was involved in FD, which may be associated with the pathogenesis of FD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Arab J Gastroenterol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China
País de publicação:
Egito