The metabolism of dibenz[a,j]acridine in the isolated perfused lung.
Cancer Lett
; 28(3): 317-26, 1985 Sep 30.
Article
em En
| MEDLINE
| ID: mdl-4053001
ABSTRACT
The metabolism of the carcinogenic N-heterocyclic aromatic, dibenz[a,j]-acridine (DB[a,j]A), was investigated in an isolated perfused rabbit lung preparation. The rate of metabolism of DB[a,j]A was less than the rate of metabolism of 7H-dibenzo[c,g]carbazole (DB[c,g]C) in the untreated and corn oil-pretreated animals. A significantly increased rate of metabolism was observed for DB[a,j]A in benzo[a]pyrene(B[a]P)-pretreated animals. This resulted in marked increases in conjugation and distribution of conjugates and total metabolites in blood and lung. Two major metabolites characterized spectroscopically were assigned as the 3,4-dihydrodiol and a phenol of DB[a,j]A. The results indicate that in the lung DB[a,j]A is metabolized in a manner similar to that of B[a]P.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acridinas
/
Carcinógenos
/
Pulmão
Limite:
Animals
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
1985
Tipo de documento:
Article