GSH-dependent inhibition of lipid peroxidation: properties of a potent cytosolic system which protects cell membranes.
Lipids
; 20(10): 704-11, 1985 Oct.
Article
em En
| MEDLINE
| ID: mdl-4058268
ABSTRACT
Properties of a heat labile, nondialyzable cytosolic factor which prevents lipid peroxidation in membranous organelles are described. The factor is present in liver and other animal tissues, and its capacity to inhibit lipid peroxidation in membranes subjected to oxidative stress is greatly potentiated by glutathione (GSH), although GSH by itself has no inhibitory effect on lipid peroxidation. The data obtained thus far indicate that one or more sulfhydryl groups associated with the factor is required for the inhibition. The mechanism by which lipid peroxidation is inhibited must involve prevention of initiation of peroxidation in the membranes, presumably by a process requiring one or more sulfhydryl groups associated with the heat labile factor. The latter appears to be protected by GSH while the factor is exerting its inhibitory effect on lipid peroxidation. The factor is not one of the known GSH-dependent enzymes, and appears to be a potent and ubiquitous system for stabilizing cell membranes against oxidative damage.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Membrana Celular
/
Glutationa
/
Peróxidos Lipídicos
/
Fígado
Limite:
Animals
Idioma:
En
Revista:
Lipids
Ano de publicação:
1985
Tipo de documento:
Article