The inactivation of bradykinin in the pulmonary circulation of isolated lungs.
Br J Pharmacol
; 45(2): 299-310, 1972 Jun.
Article
em En
| MEDLINE
| ID: mdl-4625922
ABSTRACT
1. The isolated lungs of guinea-pigs, rats and dogs, perfused with Krebs bicarbonate solution via the pulmonary artery, inactivated 95, 98 and 99% respectively of the bradykinin infused through them.2. This inactivation process was not inhibited by 2-mercaptoethanol (1 mM) or EDTA (500 muM).3. The inactivation was inhibited by 23-dimercaptopropanol (100 muM), N-ethylmaleimide (100 muM), and several of the bradykinin potentiating peptides from Bothrops jararaca, in both natural and synthetic forms.4. The effect of these compounds, 2-mercaptoethanol, EDTA, 23-dimercaptopropanol, N-ethylmaleimide and Bothrops peptides on the pulmonary bradykininase activity is the same as their effect on pulmonary angiotensin I converting enzyme.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bradicinina
/
Circulação Pulmonar
/
Pulmão
Limite:
Animals
Idioma:
En
Revista:
Br J Pharmacol
Ano de publicação:
1972
Tipo de documento:
Article