Molecular basis of drug action of some antibiotics.
J Theor Biol
; 110(4): 505-21, 1984 Oct 21.
Article
em En
| MEDLINE
| ID: mdl-6084151
ABSTRACT
A molecular model for the role of nucleoside or nucleotide analogs in drug action has been developed. This model, an extension of our earlier model has been employed to examine the possibility of incorporation of the formycin class of antibiotics (formycin, formycin B and oxoformycin B) in the growing RNA chain. Interaction energy of the analogous bases has been computed for the entire available space inside the deep groove of the DNA double helix. The values of the interaction energy thus computed along with the location of the sites of possible association are compared with the recommended configuration for RNA during transcription. It has been found that only formycin which structurally and energy-wise fulfils the requirement of the model, can successfully replace adenosine during transcription. Results are in agreement with experimental findings.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Formicinas
/
Antibióticos Antineoplásicos
/
Modelos Químicos
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
J Theor Biol
Ano de publicação:
1984
Tipo de documento:
Article