Your browser doesn't support javascript.
loading
[Antibacterial activity of MT-141 against anaerobic bacteria].
Jpn J Antibiot ; 37(6): 1058-69, 1984 Jun.
Article em Ja | MEDLINE | ID: mdl-6092738
ABSTRACT
In vitro and in vivo antibacterial activities of MT-141, a new cephamycin, against anaerobic bacteria were compared with those of cefmetazole (CMZ), cefoxitin, cefotaxime, ceftizoxime, latamoxef and cefazolin to obtain the following results. MT-141 showed high activity against a wide variety of anaerobic bacteria including B. fragilis and C. difficile except for Eubacterium lentum, E. aerofaciens and B. furcosus. Antibacterial activity of MT-141 against anaerobic bacteria was almost independent of inoculum size, medium, pH and serum addition. In vitro development of resistance of MT-141 against P. variabilis and B. fragilis was comparable to that of CMZ. Successive parenteral administration of MT-141 into mice did not cause abnormal proliferation of C. difficile. MT-141 showed excellent therapeutic effect against experimental subcutaneous abscess in mice caused by B. fragilis.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bactérias Anaeróbias / Cefamicinas Limite: Animals Idioma: Ja Revista: Jpn J Antibiot Ano de publicação: 1984 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bactérias Anaeróbias / Cefamicinas Limite: Animals Idioma: Ja Revista: Jpn J Antibiot Ano de publicação: 1984 Tipo de documento: Article