[Antibacterial activity of MT-141 against anaerobic bacteria].
Jpn J Antibiot
; 37(6): 1058-69, 1984 Jun.
Article
em Ja
| MEDLINE
| ID: mdl-6092738
ABSTRACT
In vitro and in vivo antibacterial activities of MT-141, a new cephamycin, against anaerobic bacteria were compared with those of cefmetazole (CMZ), cefoxitin, cefotaxime, ceftizoxime, latamoxef and cefazolin to obtain the following results. MT-141 showed high activity against a wide variety of anaerobic bacteria including B. fragilis and C. difficile except for Eubacterium lentum, E. aerofaciens and B. furcosus. Antibacterial activity of MT-141 against anaerobic bacteria was almost independent of inoculum size, medium, pH and serum addition. In vitro development of resistance of MT-141 against P. variabilis and B. fragilis was comparable to that of CMZ. Successive parenteral administration of MT-141 into mice did not cause abnormal proliferation of C. difficile. MT-141 showed excellent therapeutic effect against experimental subcutaneous abscess in mice caused by B. fragilis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bactérias Anaeróbias
/
Cefamicinas
Limite:
Animals
Idioma:
Ja
Revista:
Jpn J Antibiot
Ano de publicação:
1984
Tipo de documento:
Article