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Blockade of chlorpropamide alcohol flush by aspirin.
Lancet ; 1(8165): 394-6, 1980 Feb 23.
Article em En | MEDLINE | ID: mdl-6101847
The blocking effects of aspirin, chlorpheniramine, and cimetidine were tested against the flush provoked by alcohol in twenty-four chlorpropamide-treated patients with non-insulin-dependent diabetes mellitus. Active preparations were compared in a double-blind manner with an indistinguishable placebo. Aspirin significantly decreased the number of patients who flushed. Five patients studied in detail all showed suppression of chlorpropamide/alcohol flush by aspirin, with a mean facial temperature increase during the flush of 2.4 degrees C after pretreatment with placebo and an increase of 0.4 degrees C after pretreatment with aspirin.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pele / Aspirina / Clorfeniramina / Clorpropamida / Cimetidina / Diabetes Mellitus / Etanol / Face / Guanidinas Tipo de estudo: Clinical_trials Limite: Humans Idioma: En Revista: Lancet Ano de publicação: 1980 Tipo de documento: Article País de publicação: Reino Unido
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pele / Aspirina / Clorfeniramina / Clorpropamida / Cimetidina / Diabetes Mellitus / Etanol / Face / Guanidinas Tipo de estudo: Clinical_trials Limite: Humans Idioma: En Revista: Lancet Ano de publicação: 1980 Tipo de documento: Article País de publicação: Reino Unido